[PDF][PDF] On the mechanism of impairment of renal concentrating ability in hypercalcemia

A Manitius, H Levitin, D Beck… - The Journal of Clinical …, 1960 - Am Soc Clin Investig
A Manitius, H Levitin, D Beck, FH Epstein
The Journal of Clinical Investigation, 1960Am Soc Clin Investig
urea nitrogen in plasma was mildly elevated Page 1 ON THE MECHANISM OF IMPAIRMENT
OF RENAL CONCENTRATING ABILITY IN HYPERCALCEMIA * By ANDRZEJMANITIUS,t
HOWARD LEVITIN,4 DAVID BECK§ AND FRANKLIN H. EPSTEIN 11 (From the Department
of Internal Medicine, Yale University School of Medicine, New Haven,Conn.) (Submitted for
publication October 14, 1959; accepted December 17, 1959) A decrease in the ability of the
kidneys to concentrate the urine is characteristic of many varieties of experimental and clinical …
MATERIALS AND METHODS
White male Sprague-Dawley rats weighing 150 to 200 g were fed a synthetic diet containing liberal amounts of sodium and potassium (6). Forty-five animals di-
The Journal of Clinical Investigation