[HTML][HTML] Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine …
Integrin-mediated cell adhesion and signaling is required for mammary gland development
and functions. As a major mediator of integrin signaling, focal adhesion kinase (FAK) has
been implicated to play a role in the survival, proliferation, and differentiation of mammary
epithelial cells in previously studies in vitro. To assess the role of FAK in vivo, we created
mice in which FAK is selectively deleted in mammary epithelial cells. The mammary gland
FAK conditional knock-out (MFCKO) mice are viable, fertile, and macroscopically …
and functions. As a major mediator of integrin signaling, focal adhesion kinase (FAK) has
been implicated to play a role in the survival, proliferation, and differentiation of mammary
epithelial cells in previously studies in vitro. To assess the role of FAK in vivo, we created
mice in which FAK is selectively deleted in mammary epithelial cells. The mammary gland
FAK conditional knock-out (MFCKO) mice are viable, fertile, and macroscopically …