[HTML][HTML] The LIM-only proteins FHL2 and FHL3 interact with α-and β-subunits of the muscle α7β1 integrin receptor
T Samson, N Smyth, S Janetzky, O Wendler… - Journal of Biological …, 2004 - ASBMB
FHL1, FHL2, and FHL3 are members of the four and one-half LIM domain protein subclass
that are expressed in striated muscles. Here we show that FHL2 and FHL3 are novel α 7 β 1
integrin-interacting proteins. They bind both the α-and the β-subunit as well as different
splice isoforms. The minimal binding sites for FHL2 and FHL3 on β 1A-chain overlap,
whereas on α 7A and α 7B subunits they are situated adjacent. Determining the binding
sites for integrins on FHL2 or FHL3 revealed that the suprastructure of the whole molecule is …
that are expressed in striated muscles. Here we show that FHL2 and FHL3 are novel α 7 β 1
integrin-interacting proteins. They bind both the α-and the β-subunit as well as different
splice isoforms. The minimal binding sites for FHL2 and FHL3 on β 1A-chain overlap,
whereas on α 7A and α 7B subunits they are situated adjacent. Determining the binding
sites for integrins on FHL2 or FHL3 revealed that the suprastructure of the whole molecule is …