Cortical spreading depression causes and coincides with tissue hypoxia
T Takano, GF Tian, W Peng, N Lou, D Lovatt… - Nature …, 2007 - nature.com
T Takano, GF Tian, W Peng, N Lou, D Lovatt, AJ Hansen, KA Kasischke, M Nedergaard
Nature neuroscience, 2007•nature.comCortical spreading depression (CSD) is a self-propagating wave of cellular depolarization
that has been implicated in migraine and in progressive neuronal injury after stroke and
head trauma. Using two-photon microscopic NADH imaging and oxygen sensor
microelectrodes in live mouse cortex, we find that CSD is linked to severe hypoxia and
marked neuronal swelling that can last up to several minutes. Changes in dendritic
structures and loss of spines during CSD are comparable to those during anoxic …
that has been implicated in migraine and in progressive neuronal injury after stroke and
head trauma. Using two-photon microscopic NADH imaging and oxygen sensor
microelectrodes in live mouse cortex, we find that CSD is linked to severe hypoxia and
marked neuronal swelling that can last up to several minutes. Changes in dendritic
structures and loss of spines during CSD are comparable to those during anoxic …
Abstract
Cortical spreading depression (CSD) is a self-propagating wave of cellular depolarization that has been implicated in migraine and in progressive neuronal injury after stroke and head trauma. Using two-photon microscopic NADH imaging and oxygen sensor microelectrodes in live mouse cortex, we find that CSD is linked to severe hypoxia and marked neuronal swelling that can last up to several minutes. Changes in dendritic structures and loss of spines during CSD are comparable to those during anoxic depolarization. Increasing O2 availability shortens the duration of CSD and improves local redox state. Our results indicate that tissue hypoxia associated with CSD is caused by a transient increase in O2 demand exceeding vascular O2 supply.
nature.com