[HTML][HTML] Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo
M Ono, T Shimizugawa, M Shimamura… - Journal of Biological …, 2003 - ASBMB
Angiopoietin-like 3 (ANGPTL3) is a secreted protein that is mainly expressed in the liver and
regulates lipid metabolism by inhibiting the lipolysis of triglyceriderich lipoproteins. Using
deletion mutants of human ANGPTL3, we demonstrated that the N-terminal coiled-coil
domain-containing fragment-(17–207) and not the C-terminal fibrinogen-like domain-
containing fragment-(207–460) increased the plasma triglyceride levels in mice. We also
found that the N-terminal region 17–165 was required to increase plasma triglyceride levels …
regulates lipid metabolism by inhibiting the lipolysis of triglyceriderich lipoproteins. Using
deletion mutants of human ANGPTL3, we demonstrated that the N-terminal coiled-coil
domain-containing fragment-(17–207) and not the C-terminal fibrinogen-like domain-
containing fragment-(207–460) increased the plasma triglyceride levels in mice. We also
found that the N-terminal region 17–165 was required to increase plasma triglyceride levels …