Cloning, expression and characterization of a novel human REPS1 gene
Ral is a member of the small GTPase-binding protein (G protein) family, and plays an
important role in the Ras–RalGDS signal transduction pathway. A series of recent findings
reveal several important downstream target proteins of Ral, such as RalBP1, Reps1, and
others. Here we report another binding partner for RalBP1, which we have isolated from the
human fetal brain library. The human REPS1 protein shares 83% amino acid identity with
the mouse Reps1 protein. Northern blot analysis shows that the REPS1 is expressed in a …
important role in the Ras–RalGDS signal transduction pathway. A series of recent findings
reveal several important downstream target proteins of Ral, such as RalBP1, Reps1, and
others. Here we report another binding partner for RalBP1, which we have isolated from the
human fetal brain library. The human REPS1 protein shares 83% amino acid identity with
the mouse Reps1 protein. Northern blot analysis shows that the REPS1 is expressed in a …