Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects
are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and
their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in
the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake.
3) LPL gene regulation: the LPL promoter and its regulatory elements are described.