Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease
Annals of Neurology: Official Journal of the American Neurological …, 2005•Wiley Online Library
We investigated whether nonsteroidal antiinflammatory drug use was associated with a
lower risk for Parkinson's disease (PD) in a large cohort of US men and women. PD risk was
lower among ibuprofen users than nonusers. Compared with nonusers, the relative risks
were 0.73 for users of fewer than 2 tablets/week, 0.72 for 2 to 6.9 tablets/week, and 0.62 for 1
or more tablets/day (p trend= 0.03). No association was found between the use of aspirin,
other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk. The results …
lower risk for Parkinson's disease (PD) in a large cohort of US men and women. PD risk was
lower among ibuprofen users than nonusers. Compared with nonusers, the relative risks
were 0.73 for users of fewer than 2 tablets/week, 0.72 for 2 to 6.9 tablets/week, and 0.62 for 1
or more tablets/day (p trend= 0.03). No association was found between the use of aspirin,
other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk. The results …
Abstract
We investigated whether nonsteroidal antiinflammatory drug use was associated with a lower risk for Parkinson's disease (PD) in a large cohort of US men and women. PD risk was lower among ibuprofen users than nonusers. Compared with nonusers, the relative risks were 0.73 for users of fewer than 2 tablets/week, 0.72 for 2 to 6.9 tablets/week, and 0.62 for 1 or more tablets/day (p trend = 0.03). No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or acetaminophen and PD risk. The results suggest that ibuprofen use may delay or prevent the onset of PD. Ann Neurol 2005
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