[HTML][HTML] Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax
V Gogvadze, JD Robertson, B Zhivotovsky… - Journal of Biological …, 2001 - ASBMB
Release of cytochrome c from mitochondria is a key initiative step in the apoptotic process,
although the mechanisms regulating this event remain elusive. In the present study, using
isolated liver mitochondria, we demonstrate that cytochrome c release occurs via distinct
mechanisms that are either Ca 2+-dependent or Ca 2+-independent. An increase in
mitochondrial matrix Ca 2+ promotes the opening of the permeability transition (PT) pore
and the release of cytochrome c, an effect that is significantly enhanced when these …
although the mechanisms regulating this event remain elusive. In the present study, using
isolated liver mitochondria, we demonstrate that cytochrome c release occurs via distinct
mechanisms that are either Ca 2+-dependent or Ca 2+-independent. An increase in
mitochondrial matrix Ca 2+ promotes the opening of the permeability transition (PT) pore
and the release of cytochrome c, an effect that is significantly enhanced when these …