[HTML][HTML] Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores
LK Nutt, A Pataer, J Pahler, B Fang, J Roth… - Journal of Biological …, 2002 - ASBMB
Alterations in intracellular Ca 2+ homeostasis and cytochrome c release from mitochondria
have been implicated in the regulation of apoptosis, but the relationship between these
events remains unclear. Here we report that enforced expression of either Bax or Bak via
adenoviral gene delivery results in the accumulation of the proteins in the endoplasmic
reticulum (ER) and mitochondria, resulting in early caspase-independent BCL-2-sensitive
release of the ER Ca 2+ pool and subsequent Ca 2+ accumulation in mitochondria. The …
have been implicated in the regulation of apoptosis, but the relationship between these
events remains unclear. Here we report that enforced expression of either Bax or Bak via
adenoviral gene delivery results in the accumulation of the proteins in the endoplasmic
reticulum (ER) and mitochondria, resulting in early caspase-independent BCL-2-sensitive
release of the ER Ca 2+ pool and subsequent Ca 2+ accumulation in mitochondria. The …