[HTML][HTML] A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in …
EA Podrez, E Poliakov, Z Shen, R Zhang… - Journal of Biological …, 2002 - ASBMB
The macrophage scavenger receptor CD36 plays an important role in binding and uptake of
oxidized forms of low-density lipoprotein (LDL), foam cell formation, and lesion development
during atherosclerosis. The structural basis of CD36-lipoprotein ligand recognition is an
area of intense interest. In a companion article we reported the characterization of a
structurally conserved family of oxidized choline glycerophospholipids (oxPC CD36) that
serve as novel high affinity ligands for cells stably transfected with CD36, mediating …
oxidized forms of low-density lipoprotein (LDL), foam cell formation, and lesion development
during atherosclerosis. The structural basis of CD36-lipoprotein ligand recognition is an
area of intense interest. In a companion article we reported the characterization of a
structurally conserved family of oxidized choline glycerophospholipids (oxPC CD36) that
serve as novel high affinity ligands for cells stably transfected with CD36, mediating …