[HTML][HTML] Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor
CC3 (TIP30) is a protein with pro-apoptotic and anti-metastatic properties. The tumor
suppressor effect of CC3 has been suggested to result from inhibition of nuclear transport by
binding to importin βs or by regulating transcription through interaction in a complex with co-
activator independent of AF-2 function (CIA) and the c-myc gene. Previous biochemical
studies indicated that CC3 has protein kinase activity, and a structural similarity to cAMP-
dependent protein kinase catalytic subunit was proposed. By contrast, bioinformatics studies …
suppressor effect of CC3 has been suggested to result from inhibition of nuclear transport by
binding to importin βs or by regulating transcription through interaction in a complex with co-
activator independent of AF-2 function (CIA) and the c-myc gene. Previous biochemical
studies indicated that CC3 has protein kinase activity, and a structural similarity to cAMP-
dependent protein kinase catalytic subunit was proposed. By contrast, bioinformatics studies …