[HTML][HTML] cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes
B Fiedler, R Feil, F Hofmann, C Willenbockel… - Journal of Biological …, 2006 - ASBMB
Cardiac myocyte apoptosis during ischemia and reperfusion (I/R) is tightly controlled by a
complex network of stress-responsive signaling pathways. One pro-apoptotic pathway
involves the interaction of the scaffold protein TAB1 with p38 mitogen-activated protein
kinase (p38 MAPK) leading to the autophosphorylation and activation of p38 MAPK.
Conversely, NO and its second messenger cGMP protect cardiac myocytes from apoptosis
during I/R. We provide evidence that the cGMP target cGMP-dependent protein kinase type I …
complex network of stress-responsive signaling pathways. One pro-apoptotic pathway
involves the interaction of the scaffold protein TAB1 with p38 mitogen-activated protein
kinase (p38 MAPK) leading to the autophosphorylation and activation of p38 MAPK.
Conversely, NO and its second messenger cGMP protect cardiac myocytes from apoptosis
during I/R. We provide evidence that the cGMP target cGMP-dependent protein kinase type I …