[HTML][HTML] Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts
AA Roy, C Nunn, H Ming, MX Zou, J Penninger… - Journal of biological …, 2006 - ASBMB
Regulator of G protein signaling (RGS) proteins limit G protein signals. In this study, we
investigated the role of RGS2 in the control of G protein signaling cascades in osteoblasts,
the cells responsible for bone formation. Expression of RGS2 was up-regulated in primary
cultures of mouse calvarial osteoblasts by parathyroid hormone-related peptide (PTHrP)-(1-
34), which stimulates G s signaling. RGS2 was also up-regulated by extracellular ATP,
which selectively activates G q, as well as by forskolin and phorbol myristate acetate, which …
investigated the role of RGS2 in the control of G protein signaling cascades in osteoblasts,
the cells responsible for bone formation. Expression of RGS2 was up-regulated in primary
cultures of mouse calvarial osteoblasts by parathyroid hormone-related peptide (PTHrP)-(1-
34), which stimulates G s signaling. RGS2 was also up-regulated by extracellular ATP,
which selectively activates G q, as well as by forskolin and phorbol myristate acetate, which …