Regulators of G protein signalling: a spotlight on emerging functions in the cardiovascular system
T Wieland, S Lutz, P Chidiac - Current opinion in pharmacology, 2007 - Elsevier
Regulator of G protein signalling (RGS) proteins are GTPase-activating proteins for
heterotrimeric G protein α subunits, and are therefore physiologically and
pathophysiologically important negative regulators of G-protein-coupled receptor signalling
in the cardiovascular system. Owing to the functional redundancy of many of the 20 RGS,
and more than 20 RGS-like, proteins even within a single cell, animal models shedding light
on the functions of individual RGS proteins are often missing. Nevertheless, RGS2 is a …
heterotrimeric G protein α subunits, and are therefore physiologically and
pathophysiologically important negative regulators of G-protein-coupled receptor signalling
in the cardiovascular system. Owing to the functional redundancy of many of the 20 RGS,
and more than 20 RGS-like, proteins even within a single cell, animal models shedding light
on the functions of individual RGS proteins are often missing. Nevertheless, RGS2 is a …