Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA
FER Simons, Y Shikishima, G Van Nest… - Journal of Allergy and …, 2004 - Elsevier
BACKGROUND: In animal models administration of immunostimulatory DNA sequences
preferentially elicits TH1-dominated (type 1-dominated) immunity and can inhibit developing
or ongoing TH2 (type 2) responses. OBJECTIVE: Our objective was to investigate this
phenomenon in humans. METHODS: In a randomized, third party-blinded, placebo-
controlled, proof-of-concept study conducted entirely in the winter in 19 adults with ragweed
allergy, we administered 6 subcutaneous injections of purified Amb a 1 linked to the 22-base …
preferentially elicits TH1-dominated (type 1-dominated) immunity and can inhibit developing
or ongoing TH2 (type 2) responses. OBJECTIVE: Our objective was to investigate this
phenomenon in humans. METHODS: In a randomized, third party-blinded, placebo-
controlled, proof-of-concept study conducted entirely in the winter in 19 adults with ragweed
allergy, we administered 6 subcutaneous injections of purified Amb a 1 linked to the 22-base …