Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study
SP Mathupala, P Parajuli, AE Sloan - Neurosurgery, 2004 - journals.lww.com
OBJECTIVE: Dependence on glycolysis is a hallmark of malignant tumors. As a
consequence, these tumors generate more lactate, which is effluxed from cells by
monocarboxylate transporters (MCTs). We hypothesized that 1) MCT expression in
malignant tumors may differ from normal tissue in quantity, isoform, or both; and 2) silencing
MCT expression would induce intracellular acidification, resulting in decreased proliferation
and/or increased cell death. METHODS: We quantified expression of MCT isoforms in …
consequence, these tumors generate more lactate, which is effluxed from cells by
monocarboxylate transporters (MCTs). We hypothesized that 1) MCT expression in
malignant tumors may differ from normal tissue in quantity, isoform, or both; and 2) silencing
MCT expression would induce intracellular acidification, resulting in decreased proliferation
and/or increased cell death. METHODS: We quantified expression of MCT isoforms in …