[HTML][HTML] Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates
Y Li, W Lu, MP Marzolo, G Bu - Journal of Biological Chemistry, 2001 - ASBMB
The low density lipoprotein receptor (LDLR) family is composed of a class of cell surface
endocytic receptors that recognize extracellular ligands and internalize them for degradation
by lysosomes. In addition to LDLR, mammalian members of this family include the LDLR-
related protein (LRP), the very low density lipoprotein receptor (VLDLR), the apolipoprotein
E receptor-2 (apoER2), and megalin. Herein we have analyzed the endocytic functions of
the cytoplasmic tails of these receptors using LRP minireceptors, its chimeric receptor …
endocytic receptors that recognize extracellular ligands and internalize them for degradation
by lysosomes. In addition to LDLR, mammalian members of this family include the LDLR-
related protein (LRP), the very low density lipoprotein receptor (VLDLR), the apolipoprotein
E receptor-2 (apoER2), and megalin. Herein we have analyzed the endocytic functions of
the cytoplasmic tails of these receptors using LRP minireceptors, its chimeric receptor …