Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI
RZ Luo, H Peng, F Xu, J Bao, Y Pang… - … et Biophysica Acta (BBA …, 2001 - Elsevier
We have recently identified a maternally imprinted tumor suppressor gene, ARHI (aplysia
ras homolog I), the expression of which is lost in ovarian and breast cancers. We have now
characterized the genomic structure of the gene including its promoter and the methylation
status of its upstream CpG islands. The ARHI gene spans approximately 8 kb containing two
exons and one intron. Exon 1 contains 81 non-translated nucleotides, connected to exon 2
with a 3.2-kb intron. The entire protein-coding region is located within exon 2 and encodes a …
ras homolog I), the expression of which is lost in ovarian and breast cancers. We have now
characterized the genomic structure of the gene including its promoter and the methylation
status of its upstream CpG islands. The ARHI gene spans approximately 8 kb containing two
exons and one intron. Exon 1 contains 81 non-translated nucleotides, connected to exon 2
with a 3.2-kb intron. The entire protein-coding region is located within exon 2 and encodes a …