The effects of oxidative stress on the liver sieve
VC Cogger, M Muller, R Fraser, AJ McLean, J Khan… - Journal of …, 2004 - Elsevier
BACKGROUND/AIMS: Oxidative stress is implicated in the pathogenesis of age-related and
disease-associated changes in the hepatic sinusoid. We studied the effects of oxidative
stress on the morphology of the liver, focusing specifically on the hepatic sinusoidal
endothelium (the 'liver sieve'). METHODS: The effects of tert-butyl hydroperoxide on the
intact liver and isolated sinusoidal endothelial cells were assessed by electron microscopy,
immunohistochemistry and biochemical analysis. RESULTS: Immunohistochemistry …
disease-associated changes in the hepatic sinusoid. We studied the effects of oxidative
stress on the morphology of the liver, focusing specifically on the hepatic sinusoidal
endothelium (the 'liver sieve'). METHODS: The effects of tert-butyl hydroperoxide on the
intact liver and isolated sinusoidal endothelial cells were assessed by electron microscopy,
immunohistochemistry and biochemical analysis. RESULTS: Immunohistochemistry …