[HTML][HTML] Following the cytokine signaling pathway to leukemogenesis: a chronology

KA Smith, JD Griffin - The Journal of clinical investigation, 2008 - Am Soc Clin Investig
The Journal of clinical investigation, 2008Am Soc Clin Investig
Studies over the past 50 years revealing the molecular events that promote normal T
lymphocyte cycle competence and progression led to a detailed understanding of how
cytokines function to regulate normal hematopoietic cell proliferation. During that same
period, the molecular and genetic changes introduced by the Philadelphia chromosome in
chronic myelogenous leukemia were unraveled, and these have led to an understanding of
how mutations that constitutively activate normal cytokine signaling pathways can cause …
Studies over the past 50 years revealing the molecular events that promote normal T lymphocyte cycle competence and progression led to a detailed understanding of how cytokines function to regulate normal hematopoietic cell proliferation. During that same period, the molecular and genetic changes introduced by the Philadelphia chromosome in chronic myelogenous leukemia were unraveled, and these have led to an understanding of how mutations that constitutively activate normal cytokine signaling pathways can cause unregulated cell proliferation and malignant transformation. Based on the paradigm established by these data, it is inescapable that going forward, investigators will operate under the hypothesis that transformation of additional cells and tissues will have a similar pathogenesis.
The Journal of Clinical Investigation