Elevated osteopontin levels in active relapsing‐remitting multiple sclerosis
MHJ Vogt, L Lopatinskaya, M Smits… - Annals of …, 2003 - Wiley Online Library
MHJ Vogt, L Lopatinskaya, M Smits, CH Polman, L Nagelkerken
Annals of neurology, 2003•Wiley Online LibraryIn the search for proteins that might play a role in the pathogenesis of multiple sclerosis
(MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene
expressed within MS lesions. Here, we report significantly increased OPN protein levels in
plasma of relapsing‐remitting MS patients. In contrast, OPN protein levels in primary
progressive and secondary progressive MS patients were similar to healthy control levels.
Interestingly, active relapsing‐remitting patients had higher OPN protein levels than patients …
(MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene
expressed within MS lesions. Here, we report significantly increased OPN protein levels in
plasma of relapsing‐remitting MS patients. In contrast, OPN protein levels in primary
progressive and secondary progressive MS patients were similar to healthy control levels.
Interestingly, active relapsing‐remitting patients had higher OPN protein levels than patients …
Abstract
In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing‐remitting MS patients. In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels. Interestingly, active relapsing‐remitting patients had higher OPN protein levels than patients without relapses. Ann Neurol 2003;53:819–822
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