[PDF][PDF] Allergy-associated FcRβ is a molecular amplifier of IgE-and IgG-mediated in vivo responses

D Dombrowicz, S Lin, V Flamand, AT Brini, BH Koller… - Immunity, 1998 - cell.com
D Dombrowicz, S Lin, V Flamand, AT Brini, BH Koller, JP Kinet
Immunity, 1998cell.com
A role for the Fc receptor β chain (FcRβ) in the pathogenesis of allergy has been suggested
by genetic studies. FcRβ is a subunit common to the high-affinity IgE (FcεRI) and low-affinity
IgG (FcγRIII) receptors, both of which contribute to the initiation of allergic reactions. Current
in vitro data suggest that FcRβ can function as either a positive or negative regulator, leaving
a mechanistic explanation for its association with the development of atopy unclear. To
address this controversy, we have generated novel mouse models relevant to human Fc …
Abstract
A role for the Fc receptor β chain (FcRβ) in the pathogenesis of allergy has been suggested by genetic studies. FcRβ is a subunit common to the high-affinity IgE (FcεRI) and low-affinity IgG (FcγRIII) receptors, both of which contribute to the initiation of allergic reactions. Current in vitro data suggest that FcRβ can function as either a positive or negative regulator, leaving a mechanistic explanation for its association with the development of atopy unclear. To address this controversy, we have generated novel mouse models relevant to human Fc receptor function. Analysis of FcεRI- and FcγRIII-dependent responses in these mice provides unequivocal genetic evidence that FcRβ functions as an amplifier of early and late mast cell responses and, remarkably, in vivo anaphylactic responses.
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