Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models

FW Booth, DB Thomason - Physiological reviews, 1991 - journals.physiology.org
FW Booth, DB Thomason
Physiological reviews, 1991journals.physiology.org
542 FRANK W. BOOTH AND DONALD B. THOMASON Volume 71 emphasized that
biochemical and physiological adaptations to a changed environment or physiological
stimulus fall into two categories based on their duration. Cellular, organ, or systemic
alterations that occur on the same time scale as a single exercise bout are said to be acute
exercise responses. On the other hand, changes in cells, organs, or systems that persist for
appreciable periods after or as a consequence of physical training are said to be exercise …
542 FRANK W. BOOTH AND DONALD B. THOMASON Volume 71 emphasized that biochemical and physiological adaptations to a changed environment or physiological stimulus fall into two categories based on their duration. Cellular, organ, or systemic alterations that occur on the same time scale as a single exercise bout are said to be acute exercise responses. On the other hand, changes in cells, organs, or systems that persist for appreciable periods after or as a consequence of physical training are said to be exercise adaptations. A function of exercise adaptation seems to be to minimize disruption of homeostasis during an exercise bout. It is this better maintenance of the milieu interieur by the exercise adaptations that favors the functional effectiveness of the animal beyond the resting state. Less disruption in homeostasis permits the animal or human to undergo physical work for longer durations at the same absolute power before fatigue. This review considers molecular and cellular responses to exercise that may signal molecular and cellular adaptations during physical training.
American Physiological Society