[HTML][HTML] FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle
G Faulkner, A Pallavicini, A Comelli, M Salamon… - Journal of Biological …, 2000 - ASBMB
We report the identification and characterization of a novel 32-kDa protein expressed in
skeletal muscle and located in the Z-disc of the sarcomere. We found that this protein binds
to three other Z-disc proteins; therefore, we have named it FATZ, γ-filamin/ABP-L, α-actinin
andtelethonin binding protein of the Z-disc. From yeast two-hybrid experiments we are able
to show that the SR3-SR4 domains of α-actinin 2 are required to bind the COOH-terminal
region of the FATZ as does γ-filamin/ABP-L. Furthermore, by using a glutathione S …
skeletal muscle and located in the Z-disc of the sarcomere. We found that this protein binds
to three other Z-disc proteins; therefore, we have named it FATZ, γ-filamin/ABP-L, α-actinin
andtelethonin binding protein of the Z-disc. From yeast two-hybrid experiments we are able
to show that the SR3-SR4 domains of α-actinin 2 are required to bind the COOH-terminal
region of the FATZ as does γ-filamin/ABP-L. Furthermore, by using a glutathione S …