Targeting of macrophage activity by adenovirus-mediated intragraft overexpression of TNFRp55-Ig, IL-12p40, and vIL-10 ameliorates adenovirus-mediated chronic …
J Yang, A Reutzel-Selke, C Steier… - Journal of the …, 2003 - journals.lww.com
Adenovirus (Ad)–mediated gene transfer of immunoregulatory molecules prevents acute
allograft rejection. It is here analyzed for the first time whether this approach may prevent the
development of chronic renal allograft injury in rats. Renal allografts (F344→ Lewis rat) were
ex vivo transduced in group I with control Ad-construct, group II with three different
therapeutic Ad-constructs expressing the immunoregulatory molecules vIL-10, TNFRp55-Ig,
and IL-12p40, and group III with AdIFN-γ. Group IV served as untreated controls. Control …
allograft rejection. It is here analyzed for the first time whether this approach may prevent the
development of chronic renal allograft injury in rats. Renal allografts (F344→ Lewis rat) were
ex vivo transduced in group I with control Ad-construct, group II with three different
therapeutic Ad-constructs expressing the immunoregulatory molecules vIL-10, TNFRp55-Ig,
and IL-12p40, and group III with AdIFN-γ. Group IV served as untreated controls. Control …