[HTML][HTML] Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression
A Villagra, N Ulloa, X Zhang, Z Yuan… - Journal of biological …, 2007 - ASBMB
In vertebrates, a key step in the biosynthesis of cholesterol and steroid hormones is the
conversion of (S)-2, 3-oxidosqualene to lanosterol. The enzyme that catalyzes this complex
cyclization/rearrangement step via the protosteryl cation intermediate is lanosterol synthase
((S)-2, 3-epoxysqualene mutase (cyclizing, lanosterol forming), EC 5.4. 99.7). Because of
the crucial role that lanosterol synthase plays in cholesterol biosynthesis, there is great
interest in the identification of drugs that target this enzyme for anticholesteremic purposes …
conversion of (S)-2, 3-oxidosqualene to lanosterol. The enzyme that catalyzes this complex
cyclization/rearrangement step via the protosteryl cation intermediate is lanosterol synthase
((S)-2, 3-epoxysqualene mutase (cyclizing, lanosterol forming), EC 5.4. 99.7). Because of
the crucial role that lanosterol synthase plays in cholesterol biosynthesis, there is great
interest in the identification of drugs that target this enzyme for anticholesteremic purposes …