Background COPD is associated with increased numbers of CD4+ and CD8+ lymphocytes
and macrophages in the small airways and lung parenchyma. The chemokines regulating T-
cell recruitment into the lung are unknown but may involve CXCR3 and CCR5
chemoattractants. The aims of this study were to determine the concentrations of CXCR3
chemokines CXCL9, CXCL10, CXCL11, and the CCR5 chemokine CCL5 in induced sputum
from patients with COPD, smokers, and nonsmokers, and to examine the relationship …