Possible effects of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease
H Kanazawa, K Asai, K Hirata, J Yoshikawa - The American journal of …, 2003 - Elsevier
PURPOSE: Expression of vascular endothelial growth factor (VEGF) is reduced in the lungs
of patients with emphysema. We examined whether VEGF levels in sputum differed in
patients with emphysema, bronchitis, or asthma, as compared with controls. METHODS: Fifty-
nine patients with chronic obstructive pulmonary disease (COPD)(25 with emphysema, 19
with chronic bronchitis, and 15 with a mixed type), 20 patients with bronchial asthma, and 11
normal controls were included in the study. The concentration of VEGF in induced sputum …
of patients with emphysema. We examined whether VEGF levels in sputum differed in
patients with emphysema, bronchitis, or asthma, as compared with controls. METHODS: Fifty-
nine patients with chronic obstructive pulmonary disease (COPD)(25 with emphysema, 19
with chronic bronchitis, and 15 with a mixed type), 20 patients with bronchial asthma, and 11
normal controls were included in the study. The concentration of VEGF in induced sputum …