Inflammatory cells are thought to be instrumental in the pathophysiology of pulmonary
diseases, and control of their recruitment and activation in the lung would appear to be an
attractive strategy for therapeutic intervention. Interleukin-8 and related CXC chemokines
are involved in the function of neutrophils and T cells, and have been implicated in several
lung diseases. Small-molecule antagonists of the interleukin-8 receptors have been
identified, which may help elucidate the role of interleukin-8 and related chemokines in the …