[HTML][HTML] SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL
L Yvan-Charvet, TA Pagler, N Wang, T Senokuchi… - Journal of lipid …, 2008 - ASBMB
This study compares the roles of ABCG1 and scavenger receptor class B type I (SR-BI)
singly or together in promoting net cellular cholesterol efflux to plasma HDL containing
active LCAT. In transfected cells, SR-BI promoted free cholesterol efflux to HDL, but this was
offset by an increased uptake of HDL cholesteryl ester (CE) into cells, resulting in no net
efflux. Coexpression of SR-BI with ABCG1 inhibited the ABCG1-mediated net cholesterol
efflux to HDL, apparently by promoting the reuptake of CE from medium. However, ABCG1 …
singly or together in promoting net cellular cholesterol efflux to plasma HDL containing
active LCAT. In transfected cells, SR-BI promoted free cholesterol efflux to HDL, but this was
offset by an increased uptake of HDL cholesteryl ester (CE) into cells, resulting in no net
efflux. Coexpression of SR-BI with ABCG1 inhibited the ABCG1-mediated net cholesterol
efflux to HDL, apparently by promoting the reuptake of CE from medium. However, ABCG1 …