[PDF][PDF] The biological functions of T helper 17 cell effector cytokines in inflammation
T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the
traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of
interleukin-17A (IL-17A), IL-17F, IL-21, and IL-22. Th17 cells and their effector cytokines
mediate host defensive mechanisms to various infections, especially extracellular bacteria
infections, and are involved in the pathogenesis of many autoimmune diseases. The
receptors for IL-17 and IL-22 are broadly expressed on various epithelial tissues. The …
traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of
interleukin-17A (IL-17A), IL-17F, IL-21, and IL-22. Th17 cells and their effector cytokines
mediate host defensive mechanisms to various infections, especially extracellular bacteria
infections, and are involved in the pathogenesis of many autoimmune diseases. The
receptors for IL-17 and IL-22 are broadly expressed on various epithelial tissues. The …
T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of interleukin-17A (IL-17A), IL-17F, IL-21, and IL-22. Th17 cells and their effector cytokines mediate host defensive mechanisms to various infections, especially extracellular bacteria infections, and are involved in the pathogenesis of many autoimmune diseases. The receptors for IL-17 and IL-22 are broadly expressed on various epithelial tissues. The effector cytokines of Th17 cells, therefore, mediate the crucial crosstalk between immune system and tissues, and play indispensable roles in tissue immunity.
cell.com