[HTML][HTML] Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replication
GM Argast, JS Campbell, JT Brooling… - Journal of Biological …, 2004 - ASBMB
Tumor necrosis factor (TNF) has multiple biological effects such as participating in
inflammation, apoptosis, and cell proliferation, but the mechanisms of its effects on epithelial
cell proliferation have not been examined in detail. At the early stages of liver regeneration,
TNF functions as a priming agent for hepatocyte replication and increases the sensitivity of
hepatocytes to growth factors such as transforming growth factor α (TGFα); however, the
mechanisms by which TNF interacts with growth factors and enhances hepatocyte …
inflammation, apoptosis, and cell proliferation, but the mechanisms of its effects on epithelial
cell proliferation have not been examined in detail. At the early stages of liver regeneration,
TNF functions as a priming agent for hepatocyte replication and increases the sensitivity of
hepatocytes to growth factors such as transforming growth factor α (TGFα); however, the
mechanisms by which TNF interacts with growth factors and enhances hepatocyte …