Monoclonal cytolytic T-cell lines.
PE Baker, S Gillis, KA Smith - The Journal of experimental medicine, 1979 - ncbi.nlm.nih.gov
PE Baker, S Gillis, KA Smith
The Journal of experimental medicine, 1979•ncbi.nlm.nih.govMonospecific cloned cytolytic T-lymphocyte lines have been created utilizing T-cell growth
factor. The clones were found to retain their cytolytic specificity after prolonged culture and
monospecific function was demonstrated by subcloning procedures. Thus, detailed studies
of the phenotypic and functional characteristics of monospecific, homogeneous, cytolytic T
lymphocytes will now be possible.
factor. The clones were found to retain their cytolytic specificity after prolonged culture and
monospecific function was demonstrated by subcloning procedures. Thus, detailed studies
of the phenotypic and functional characteristics of monospecific, homogeneous, cytolytic T
lymphocytes will now be possible.
Abstract
Monospecific cloned cytolytic T-lymphocyte lines have been created utilizing T-cell growth factor. The clones were found to retain their cytolytic specificity after prolonged culture and monospecific function was demonstrated by subcloning procedures. Thus, detailed studies of the phenotypic and functional characteristics of monospecific, homogeneous, cytolytic T lymphocytes will now be possible.
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