Immune response and mitosis of human peripheral blood lymphocytes in vitro
K Hirschhorn, F Bach, RL Kolodny, IL Firschein… - Science, 1963 - science.org
K Hirschhorn, F Bach, RL Kolodny, IL Firschein, N Hashem
Science, 1963•science.orgPhytohemagglutinin causes cultured lymphocytes to agglutinate, divide, and produce γ-
globulin. Most cells are transformed into large lymphocytes, some resembling plasmocytes.
Actinomycin D stops γ-globulin production after 2 hours. When specific antigens are added
to lymphocytes from sensitized individuals, only some cells undergo morphological
transformation, produce γ-globulin, and divide. When cells or cell extracts from an unrelated
individual are added to a culture, a similar reaction occurs.
globulin. Most cells are transformed into large lymphocytes, some resembling plasmocytes.
Actinomycin D stops γ-globulin production after 2 hours. When specific antigens are added
to lymphocytes from sensitized individuals, only some cells undergo morphological
transformation, produce γ-globulin, and divide. When cells or cell extracts from an unrelated
individual are added to a culture, a similar reaction occurs.
Phytohemagglutinin causes cultured lymphocytes to agglutinate, divide, and produce γ-globulin. Most cells are transformed into large lymphocytes, some resembling plasmocytes. Actinomycin D stops γ-globulin production after 2 hours. When specific antigens are added to lymphocytes from sensitized individuals, only some cells undergo morphological transformation, produce γ-globulin, and divide. When cells or cell extracts from an unrelated individual are added to a culture, a similar reaction occurs.
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