[HTML][HTML] Transcytosis of lipoprotein lipase across cultured endothelial cells requires both heparan sulfate proteoglycans and the very low density lipoprotein receptor
JC Obunike, EP Lutz, Z Li, L Paka, T Katopodis… - Journal of Biological …, 2001 - ASBMB
Lipoprotein lipase (LPL), the major enzyme responsible for the hydrolysis of circulating
lipoprotein triglyceride molecules, is synthesized in myocytes and adipocytes but functions
while bound to heparan sulfate proteoglycans (HSPGs) on the luminal surface of vascular
endothelial cells. This requires transfer of LPL from the abluminal side to the luminal side of
endothelial cells. Studies were performed to investigate the mechanisms of LPL transcytosis
using cultured monolayers of bovine aortic endothelial cells. We tested whether HSPGs and …
lipoprotein triglyceride molecules, is synthesized in myocytes and adipocytes but functions
while bound to heparan sulfate proteoglycans (HSPGs) on the luminal surface of vascular
endothelial cells. This requires transfer of LPL from the abluminal side to the luminal side of
endothelial cells. Studies were performed to investigate the mechanisms of LPL transcytosis
using cultured monolayers of bovine aortic endothelial cells. We tested whether HSPGs and …