[HTML][HTML] Effect of the apolipoprotein A-IV Q360H polymorphism on postprandial plasma triglyceride clearance
KJ Hockey, RA Anderson, VR Cook, RR Hantgan… - Journal of Lipid …, 2001 - ASBMB
Apolipoprotein (apo) A-IV is synthesized in the small intestine during fat absorption and is
incorporated onto the surface of nascent chylomicrons. In circulation, apoA-IV is displaced
from the chylomicron surface by high density lipoprotein-associated C and E
apolipoproteins; this exchange is critical for activation of lipoprotein lipase and chylomicron
remnant clearance. The variant allele A-IV-2 encodes a Q360H polymorphism that increases
the lipid affinity of the apoA-IV-2 isoprotein. We hypothesized that this would impede the …
incorporated onto the surface of nascent chylomicrons. In circulation, apoA-IV is displaced
from the chylomicron surface by high density lipoprotein-associated C and E
apolipoproteins; this exchange is critical for activation of lipoprotein lipase and chylomicron
remnant clearance. The variant allele A-IV-2 encodes a Q360H polymorphism that increases
the lipid affinity of the apoA-IV-2 isoprotein. We hypothesized that this would impede the …