[HTML][HTML] In vivo evidence of a role for hepatic lipase in human apoB-containing lipoprotein metabolism, independent of its lipolytic activity
A Zambon, SS Deeb, A Bensadoun, KE Foster… - Journal of Lipid …, 2000 - ASBMB
Hepatic lipase (HL) is a key player in lipoprotein metabolism by modulating, through its
lipolytic activity, the triglyceride (TG) and phospholipid content of apolipoprotein B (apoB)-
containing lipoproteins and of high density lipoproteins (HDL), thereby affecting their size
and density. A new and separate role has been suggested for HL in cellular lipoprotein
metabolism, in which it serves as a ligand promoting cellular uptake of apoB-containing
remnant lipoproteins and HDL. We tested the hypothesis that HL has both a lipolytic and a …
lipolytic activity, the triglyceride (TG) and phospholipid content of apolipoprotein B (apoB)-
containing lipoproteins and of high density lipoproteins (HDL), thereby affecting their size
and density. A new and separate role has been suggested for HL in cellular lipoprotein
metabolism, in which it serves as a ligand promoting cellular uptake of apoB-containing
remnant lipoproteins and HDL. We tested the hypothesis that HL has both a lipolytic and a …