[HTML][HTML] Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8
L Yu, J York, K Von Bergmann, D Lutjohann… - Journal of Biological …, 2003 - ASBMB
Liver X receptor (LXR) is a nuclear receptor that plays a crucial role in orchestrating the
trafficking of sterols between tissues. Treatment of mice with a potent and specific LXR
agonist, T0901317, is associated with increased biliary cholesterol secretion, decreased
fractional cholesterol absorption, and increased fecal neutral sterol excretion. Here we show
that expression of two target genes of LXRα, the ATP-binding cassette (ABC)
transportersAbcg5 and Abcg8, is required for both the increase in sterol excretion and the …
trafficking of sterols between tissues. Treatment of mice with a potent and specific LXR
agonist, T0901317, is associated with increased biliary cholesterol secretion, decreased
fractional cholesterol absorption, and increased fecal neutral sterol excretion. Here we show
that expression of two target genes of LXRα, the ATP-binding cassette (ABC)
transportersAbcg5 and Abcg8, is required for both the increase in sterol excretion and the …