Epigenetic regulation of established human type 1 versus type 2 cytokine responses
RC Su, AB Becker, AL Kozyrskyj… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Multiple biologic factors influence maintenance of immunologic
responsiveness. Here, we studied whether epigenetics has a regulatory function in
maintaining pre-established TH1-like and TH2-like immunity in human beings. OBJECTIVE:
We focused on delineating the role of endogenous histone deacetylase (HDAC) activity in
regulating cytokine recall responses. METHODS: Using RT-PCR and ELISA, the effect of
increasing cellular acetylation on TH1/TH2 cytokine expression was systematically …
responsiveness. Here, we studied whether epigenetics has a regulatory function in
maintaining pre-established TH1-like and TH2-like immunity in human beings. OBJECTIVE:
We focused on delineating the role of endogenous histone deacetylase (HDAC) activity in
regulating cytokine recall responses. METHODS: Using RT-PCR and ELISA, the effect of
increasing cellular acetylation on TH1/TH2 cytokine expression was systematically …