[PDF][PDF] NKG2D blockade prevents autoimmune diabetes in NOD mice
K Ogasawara, JA Hamerman, LR Ehrlich… - Immunity, 2004 - cell.com
Immunity, 2004•cell.com
NKG2D is an activating receptor on CD8+ T cells and NK cells that has been implicated in
immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in
prediabetic pancreas islets of NOD mice and that autoreactive CD8+ T cells infiltrating the
pancreas express NKG2D. Treatment with a nondepleting anti-NKG2D monoclonal antibody
(mAb) during the prediabetic stage completely prevented disease by impairing the
expansion and function of autoreactive CD8+ T cells. These findings demonstrate that …
immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in
prediabetic pancreas islets of NOD mice and that autoreactive CD8+ T cells infiltrating the
pancreas express NKG2D. Treatment with a nondepleting anti-NKG2D monoclonal antibody
(mAb) during the prediabetic stage completely prevented disease by impairing the
expansion and function of autoreactive CD8+ T cells. These findings demonstrate that …
Abstract
NKG2D is an activating receptor on CD8+ T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8+ T cells infiltrating the pancreas express NKG2D. Treatment with a nondepleting anti-NKG2D monoclonal antibody (mAb) during the prediabetic stage completely prevented disease by impairing the expansion and function of autoreactive CD8+ T cells. These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes.
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