[HTML][HTML] Tyrosine phosphorylation of VE-cadherin prevents binding of p120-and β-catenin and maintains the cellular mesenchymal state
MD Potter, S Barbero, DA Cheresh - Journal of Biological Chemistry, 2005 - ASBMB
In several pathological conditions, epithelial cells demonstrate a breakdown of barrier
function and acquire an invasive phenotype. Endothelial cells in particular are maintained in
a mesenchymal state during the cell invasion phase of angiogenesis. We show here that
tyrosine phosphorylation of the adherens junction protein VE-cadherin at two critical
tyrosines, Tyr-658 and Tyr-731, via tyrosine kinase activation or phosphatase inactivation
was sufficient to prevent the binding of p120-and β-catenin, respectively, to the cytoplasmic …
function and acquire an invasive phenotype. Endothelial cells in particular are maintained in
a mesenchymal state during the cell invasion phase of angiogenesis. We show here that
tyrosine phosphorylation of the adherens junction protein VE-cadherin at two critical
tyrosines, Tyr-658 and Tyr-731, via tyrosine kinase activation or phosphatase inactivation
was sufficient to prevent the binding of p120-and β-catenin, respectively, to the cytoplasmic …