[HTML][HTML] Receptor specificity of the fibroblast growth factor family: the complete mammalian FGF family
In mammals, fibroblast growth factors (FGFs) are encoded by 22 genes. FGFs bind and
activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1–4). The
spatial and temporal expression patterns of FGFs and FGFRs and the ability of specific
ligand-receptor pairs to actively signal are important factors regulating FGF activity in a
variety of biological processes. FGF signaling activity is regulated by the binding specificity
of ligands and receptors and is modulated by extrinsic cofactors such as heparan sulfate …
activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1–4). The
spatial and temporal expression patterns of FGFs and FGFRs and the ability of specific
ligand-receptor pairs to actively signal are important factors regulating FGF activity in a
variety of biological processes. FGF signaling activity is regulated by the binding specificity
of ligands and receptors and is modulated by extrinsic cofactors such as heparan sulfate …