The herpes simplex virus type 1 ICP6 gene is regulated by a 'leaky'early promoter
P Sze, RC Herman - Virus research, 1992 - Elsevier
Expression from the promoter for the large subunit (ICP6) of the ribonucleotide reductase
encoded by herpes simplex virus type 1 (HSV-1) has been examined. Using the lacZ
reporter gene fused in-frame with ICP6 regulatory sequences to assay expression
quantitatively, we showed that the ICP6 promoter responded very weakly to the alpha-
transinducing factor (TIF) in the absence of all other viral gene products, but much more
strongly to immediate early proteins. Similar patterns of regulation were observed when the …
encoded by herpes simplex virus type 1 (HSV-1) has been examined. Using the lacZ
reporter gene fused in-frame with ICP6 regulatory sequences to assay expression
quantitatively, we showed that the ICP6 promoter responded very weakly to the alpha-
transinducing factor (TIF) in the absence of all other viral gene products, but much more
strongly to immediate early proteins. Similar patterns of regulation were observed when the …