[HTML][HTML] Substrate Control of Free Radical Generation from Xanthine Oxidase in the Postischemic Heart (∗)
Y Xia, JL Zweier - Journal of Biological Chemistry, 1995 - ASBMB
While the free radical-generating enzyme xanthine oxidase is a central mechanism of injury
in postischemic tissues, questions remain regarding how xanthine oxidase-mediated radical
generation is triggered during ischemia and reperfusion. There is controversy regarding
whether radical generation is caused by enzyme formation or that of its substrates xanthine
and hypoxanthine. Therefore, studies were performed in isolated rat hearts correlating the
magnitude and time course of radical generation with alterations in xanthine oxidase and its …
in postischemic tissues, questions remain regarding how xanthine oxidase-mediated radical
generation is triggered during ischemia and reperfusion. There is controversy regarding
whether radical generation is caused by enzyme formation or that of its substrates xanthine
and hypoxanthine. Therefore, studies were performed in isolated rat hearts correlating the
magnitude and time course of radical generation with alterations in xanthine oxidase and its …