Stimulation of human and murine adherent cells by bacterial lipoprotein and synthetic lipopeptide analogues

P Hoffmann, S Heinle, UF Schade, H Loppnow… - Immunobiology, 1988 - Elsevier
Lipoprotein from the outer membrane of Escherichia coli and its synthetically prepared N-
terminal lipopeptide segments Pam 3 Cys-Ser-Ser-Asn-Ala and Pam 3 Cys-Ser, as well as
lipo-protein from other Enterobacteriaceae, constitute potent polyclonal B lymphocyte
activators. Here, we demonstrate that these compounds were also able to stimulate human
and murine leukocytes: in murine macrophages, we could show the induction of interleukin
1 release by the mitogens, as measured in the thymocyte proliferation assay. Moreover …