[HTML][HTML] The Lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-κB activation in epithelial cells in a Toll-like receptor 2-dependent manner

PL Fisette, S Ram, JM Andersen, W Guo… - Journal of Biological …, 2003 - ASBMB
The human pathogen Neisseria gonorrhoeae produces an array of diseases ranging from
urethritis to disseminated gonococcal infections. Early events in the establishment of
infection involve interactions between N. gonorrhoeae and the mucosal epithelium, which
leads to the local release of inflammatory mediators. Because of this, it is important to
identify the bacterial virulence factors and host cell components that contribute to
inflammation. Using a series of column chromatography steps, we purified a lipoprotein from …