Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4+ T Cells

ZQ Zhang, T Schuler, M Zupancic, S Wietgrefe… - Science, 1999 - science.org
ZQ Zhang, T Schuler, M Zupancic, S Wietgrefe, KA Staskus, KA Reimann, TA Reinhart…
Science, 1999science.org
In sexual transmission of simian immunodeficiency virus, and early and later stages of
human immunodeficiency virus–type 1 (HIV-1) infection, both viruses were found to replicate
predominantly in CD4+ T cells at the portal of entry and in lymphoid tissues. Infection was
propagated not only in activated and proliferating T cells but also, surprisingly, in resting T
cells. The infected proliferating cells correspond to the short-lived population that produces
the bulk of HIV-1. Most of the HIV-1–infected resting T cells persisted after antiretroviral …
In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus–type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4+ T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV-1–infected resting T cells persisted after antiretroviral therapy. Latently and chronically infected cells that may be derived from this population pose challenges to eradicating infection and developing an effective vaccine.
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