The ability of an environmental exposure to induce an epigenetic transgenerational adult
onset disease phenotype is discussed in the current mini-review in the context of defining
this phenomenon and the associated reproductive toxicology. A gestating female (F0
generation) exposure to an environmental compound results in the F1 generation embryo
and F2 generation germ-line being directly exposed, such that the F3 generation is the first
not directly exposed to the environmental compound. In contrast, postnatal or adult exposure …