Declining T-cell immunity to influenza, 1977-82
AJ McMichael, DW Dongworth, FM Gotch, A Clark… - The Lancet, 1983 - Elsevier
AJ McMichael, DW Dongworth, FM Gotch, A Clark, CW Potter
The Lancet, 1983•ElsevierAbstract Influenza-A-virus-specific, HLA-restricted, cytotoxic T-cell immunity, measured in
189 volunteers in the six years 1977-82, showed a sharp decline from 1978. It is shown that
natural infection with influenza-A virus boosts cytotoxic T-cell memory. The decline in T-cell
immunity is probably associated with the low prevalence of influenza-A-virus infection since
1978.
189 volunteers in the six years 1977-82, showed a sharp decline from 1978. It is shown that
natural infection with influenza-A virus boosts cytotoxic T-cell memory. The decline in T-cell
immunity is probably associated with the low prevalence of influenza-A-virus infection since
1978.
Abstract
Influenza-A-virus-specific, HLA-restricted, cytotoxic T-cell immunity, measured in 189 volunteers in the six years 1977-82, showed a sharp decline from 1978. It is shown that natural infection with influenza-A virus boosts cytotoxic T-cell memory. The decline in T-cell immunity is probably associated with the low prevalence of influenza-A-virus infection since 1978.
Elsevier